The Postdoc will join Professor Eric Gaucher’s group and be tasked with using their knowledge of gene editing to design and implement gene editing systems for independent and collaborative purposes (20%). In particular, the Postdoc will use CRISPR/CAS9 technology to reactivate the human uricase gene (wild-type gene is inactive) in human liver cells and devise various strategies to accomplish this aim (30%). Expertise of molecular and cellular assays will be utilized to characterize the downstream effects of gene editing (30%).
In addition to research, this position will offer career training opportunities to expand the Postdoc’s development in a creative and interactive environment. The Postdoc will be expected to serve as a mentor to graduate and undergraduate students, publish abstracts and manuscripts in peer-reviewed journals, as well as present at local, national, and international venues (20%).
• Expertise in synthetic biology and microbial assays (synthetic gene/construct design, genetic manipulation, protein production and characterization, cellular-based assays, etc.)
• Experience with mammalian cell culture and bacterial cell culture
• Engineer, implement, and troubleshoot a system for gene editing strategies (emphasis on CRISPR/CAS9-based systems)
• Knowledge of constructing gRNA and/or Cas9 modifications to manipulate activity
• Highly skilled in gene editing and screening, cell manipulation, and physiological characterization
• Strong proficiency in utilizing molecular and cellular assays to observe the downstream effects of gene editing
• Proven ability to work independently and in collaborative team environments
Please submit a complete curriculum vitae (CV), cover letter, contact information for 2-3 references, and proof of academic status. Applicant must have a PhD in Biology, Biotechnology/Bioengineering, Microbiology, Molecular Biology or other related disciplines with relevant experience.